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论文摘要

实验性骨质疏松对种植体周自体骨移植愈合影响的研究

The effect of experimental osteoporosis on bone healing of autologous iliac crest graft around implants

作者:李剑平 张望群 于静 戚孟春 胡静 王东胜

Author:LI Jian-ping1, ZHANG Wang-qun1, YU Jing1, QI Meng-chun1, HU Jing2, WANG Dong-sheng3

收稿日期:2010-08-25          年卷(期)页码:2010,28(04):435-435-438

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:种植牙,自体髂骨移植,骨质疏松,骨结合,

Key words:dental implant,autologous iliac crest graft,osteoporosis,osseointegration,

基金项目:

河北省科技厅基金资助项目(08276101D-73);河北省教育厅基金资助项目(2008322)

中文摘要

目的研究实验性骨质疏松(OP)对兔种植体周自体骨移植愈合的影响。方法将20只雌性日本大耳白兔随机分成对照组和实验组,实验组行双侧卵巢切除术,对照组接受假手术。术后12周测量股骨骨密度(BMD),证实OP状态。同时在2组家兔左侧胫骨近中干骺端制备骨缺损,行自体髂骨移植和同期种植体植入手术。植骨术后第8、12周分2批处死动物,切取标本制作不脱钙硬组织切片,进行组织形态学观察和骨计量学检测。结果实验组BMD显著低于对照组(P

英文摘要

Objective To investigate the influences of experimental osteoporosis(OP) on bone healing of autologous iliac crest graft around dental implants in rabbits. Methods Twenty Japanese rabbits were randomly divided into two groups. Bilaterally ovariectomy was performed on experimental group and control group received sham-operation. Twelve weeks later, femoral bones were examined for bone mineral density(BMD) to verify OP status. Then bone defects were made in the proximal metaphysis of the tibiae and autologous iliac crest grafts with simultaneous implant placement were performed. The animals were killed at 8 and 12 weeks after bone graft surgery. Undecalcified sections were prepared and examined histologically and histomorphometrically. Results Osteoporotic status caused by ovariectomy was verified by significantly decreased BMD in experimental group(P

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