Objective To investigate the influences of experimental osteoporosis(OP) on bone healing of autologous iliac crest graft around dental implants in rabbits. Methods Twenty Japanese rabbits were randomly divided into two groups. Bilaterally ovariectomy was performed on experimental group and control group received sham-operation. Twelve weeks later, femoral bones were examined for bone mineral density(BMD) to verify OP status. Then bone defects were made in the proximal metaphysis of the tibiae and autologous iliac crest grafts with simultaneous implant placement were performed. The animals were killed at 8 and 12 weeks after bone graft surgery. Undecalcified sections were prepared and examined histologically and histomorphometrically. Results Osteoporotic status caused by ovariectomy was verified by significantly decreased BMD in experimental group(P