Objective To evaluate the relationship between periodontitis and the traditional risk factors of coronar heart disease（CHD）, as well as the role in the mechanisms responsible for high-sensitivity C-reactive protein （hsCRP） in the relationship of peridontitis and CHD. Methods A periodontal examination was conducted on a total of 356 subjects, and community periodontal index of treatment needs（CPITN） was obtained from each subject. Periodontal status was categorized into TN≤2, TN=3, TN=4 three groups according to the CPITN indexes. Fasting venous blood samples were collected from all the three group subjects, the serum hsCRP concentration and serological changes used in diagnosing CHD routinely were determined, and software of SPSS 16.0 were used to analyzed the relationship of periodontal, hsCRP concentration and routinely CHD serological indexes. Results In the groups of TN≤2, TN=3 and TN=4, the hsCRP level was （1.10±1.16）, （1.86±2.34）, （2.25±2.75） mg·L-1, respectively. Compared with Group TN≤2, the concentration of hsCRP in Group TN=3 and TN=4 were higher（OR=1.24, OR=1.31, respectively）. Compared with group hsCRP＜3.0 mg·L-1, more calculus and deep periodontal pockets were found in the Group hsCRP≥3.0 mg·L-1（P＜0.05）. Conclusion The serum hsCRP level is correlated with the severity of periodontal disease.
