Objective To investigate the effects of C-reactive protein(CRP) on monocytes chemotaxis ability in vitro. Methods Transwell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP -1 monocytes in each group treated with CRP in different concentration. Results CRP increased the number of attracted monocytes in response to MCP-1(monocyte chemoattractant protein-1). When treated with CRP concentration at 2 μg·mL-1, the number of chemotactic monocytes increased(P