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论文摘要

新型骨组织工程支架材料生物相容性的体内研究

Biocompatibility of new bone tissue engineering scaffolds in vivo

作者:李轶 冉炜 王改玲 景向东

Author:LI Yi1, RAN Wei2, WANG Gai-ling1, JING Xiang-dong1

收稿日期:2009-08-25          年卷(期)页码:2009,27(04):447-

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:骨组织工程,支架材料,下颌骨缺损,

Key words:bone tissue engineering,scaffold material,mandibular defect,

基金项目:

广东省自然科学基金资助项目(990621)

中文摘要

目的通过比较2种新型骨组织工程支架材料即聚消旋乳酸/聚乳酸-聚乙二醇-聚乳酸/磷酸三钙(A)、聚消旋乳酸/聚乳酸-聚乙二醇-聚乳酸(B)与对照组聚消旋乳酸(C)修复兔下颌骨缺损的效果,探讨新型可吸收性生物支架材料体内埋植的生物相容性。方法24只成年新西兰大白兔按取材时间随机分为4组。双侧下颌骨下缘形成15 mm×6 mm全层骨质缺损, 每一缺损作为一个实验单位。每组内按完全随机化设计植入实验材料和对照材料。术后2、4、8、12周取材行大体标本、X线、组织学观察及计算机图像分析。结果复合支架材料A、B与聚消旋乳酸相比,复合支架B生物相容性好,同期成骨量最大;复合支架A出现明显的异物肉芽肿反应。结论新型复合支架材料B生物相容性好,效果优于聚消旋乳酸,有可能成为一种较理想的支架材料。复合支架A不适宜作为骨组织工程生物支架材料。

英文摘要

Objective To investigate the biocompatibility of new bone tissue engineering scaffolds, A:D, L-polylactic acid(PDLLA)/polylactic acid-polyethylene glycol-polylactic acid-polylactic acid(PLA-PEG-PLA)/Tricalcium phosphate and B: PDLLA/PLA -PEG -PLA in vivo, compared with PDLLA in repair of a rabbit mandibular body defect. Methods 24 New Zealand adult rabbits were divided into 4 groups randomly. 15 mm×6 mm defects were made surgically in the bilateral mandibular bodies and each hemi-mandible was assigned as an experimental unit. The defects were randomly repaired with scaffold materials in each group. Specimens obtained were evaluated with general observation, X-ray, histomorphology and computerized graphical analysis at 2, 4 , 8, 12 weeks after surgery. Results Compared with PDLLA, the new scaffold materials B showed biocompatibility. At the same time the quantity of new bone produced was much more than that in control group(P

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