口腔黏膜癌变过程中丝氨酸/苏氨酸激酶15的表达及意义
The over-expression of serine/threonine kinase 15 protein in oral carcinogenesis
作者：卢虹 蔡扬 于燕妮 杨宏
Author：LU Hong1, CAI Yang1, YU Yan-ni2, YANG Hong1
收稿日期：2009-02-25 年卷（期）页码：2009,27(01):88-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：丝氨酸/苏氨酸激酶15,癌前损害,异常增生,鳞状细胞癌,
Key words：serine/threonine kinase 15,precancerous lesions,dysplasia,squamous cell carcinoma,
基金项目：
国家自然科学基金资助项目（30460139）；教育部留学回国人员科研启动基金资助项目（N2005-1）
中文摘要
目的了解丝氨酸/苏氨酸激酶15（STK15）在口腔黏膜癌变过程中的表达变化，探讨P53/STK15转激活-非依赖通路在口腔鳞癌（OSCC）发生发展中的作用及意义。方法正常口腔黏膜8例，上皮异常增生患者27例，OSCC患者43例, 石蜡包埋组织，采用免疫组化SABC法了解STK15及P53蛋白表达情况，分析二者的相关性及其临床病理学意义。结果STK15在正常口腔黏膜无表达，在上皮异常增生及OSCC中阳性率分别为40.74%（11/27） 和67.44%（29/43），各组间差异均有统计学意义（P
英文摘要
Objective To investigate the expression of STK15 and P53 proteins in oral precancerous lesions and oral squamous cell carcinoma（OSCC） and elucidate the possible role of P53/STK15 switch activation -indep dendent pathway in oral carcinogenesis. Methods Formalin -fixed, paraffin -embedded tissues of 8 cases of normal oral epithelium, 27 cases of dysplasia with different degree epithelium dysplasia and 43 cases of OSCC with different differentiation were investigated for the expression of STK15 and P53 proteins by using immunohistochemistry. The clinical and pathological significance of STK15 over-expression in oral carcinogenesis were statistically analyzed by SPSS 12.0. Results STK15 protein was not detectable in normal oral epithelium and significantly altered from milddysplasia to OSCC. The percentage of STK15 over-expression were 40.74%（11/27） in dysplasia and 67.44%（29/43） in OSCC（P
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