Objective To study the clinical effect of Gelatamp colloidal silver gelatin sponge on preventing the complication of teeth extraction. Methods 672 teeth were divided into experimental group and control group semirandomly. All teeth were extracted after local anesthesia and sockets were cleaned. Gelatamp colloidal silver gelatin sponge was implanted into socket in experimental group and nothing was implanted into alveolar socket in control group. The complication of teeth extraction was observed on 0.5 h, 2 d and 7 d after extraction. The incidence rate of complication was calculated. Results The incidence rate of complication of teeth extraction in experimental group was 7.72%, which was lower than that of control group(24.43%). There was significant difference in the incidence rates of complication between experimental group and control group(P