Objective To study the clinical significance of osteopontin（OPN） and its receptor CD44v6 expression in oral squamous cell carcinoma（OSCC）. Methods OPN and CD44v6 expression were examined in OSCC（n=59）and normal oral mucosa（n=12）by EnVisionTM method, the staining- grade were quantitatively studied by multiple functional image analyzer. Their expression grade of different clinical and pathological index were statistically studied. Results OPN expression grade was significantly higher in OSCC than that in normal oral mucosa（P
