Objective To evaluate the clinical application effect of a three- dimensional craniomaxillofacial measurement instrument. Methods A three- dimensional craniomaxillofacial measurement instrument was developed. Twelve patients of unilateral fracture of zygoma complex were treated with the help of the three- dimensional craniomaxillofacial measurement instrument. Results The therapeutic effects of twelve patients were satisfactory with the threedimensional craniomaxillofacial measurement instrument. No complication occurred, such as infection, injury of nerves and veins. Conclusion Three - dimensional craniomaxillofacial measurement instrument can exactly measure craniomaxillofacial hard tissue, and has adjuvant effect to restore and fix the fracture of unilateral zygoma complex.