Objective To observe the effect of oral carcinoma-associated fibroblasts（CAFs） on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma（OSCC） progression. Methods Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113. Results Compared with normal fibroblasts（NFs）, CAFs promoted more Tca8113 cells to penetrate Matrigel（PTca8113, and play a key role in OSCC progression.
