复合骨形成蛋白治疗剂治疗根尖周病的动物实验研究
Animal Experimental Study of the Treatment of Periapical Disease with Recombinant Human Bone Morphogenetic Pro- tein-2 Composite
作者：彭华光,汪竹平,刘亭彦,王铎
Author：PENGHua-guang1,WANG Zhu-ping2,LIUTing-yan1,WANG Duo2
收稿日期：2005-06-25 年卷（期）页码：2005,23(03):204-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：重组人骨形成蛋白-2,根尖周病,根管治疗,
Key words：recombinant human bone morphogenetic protein,periapical disease,root canal therapy,
基金项目：山东省科委科研基金资助项目(413773)
中文摘要
目的 观察复合重组人骨形成蛋白-2 (rhBMP-2)治疗剂治疗狗牙实验性根尖周病的疗效。方法 采用根
管内封入内毒素细菌混合液的方法建立根尖周病动物模型,将由rhBMP-2、磷酸三钙、胶原和甲硝唑制成的复合rh-
BMP-2治疗剂作为根尖屏障用于狗牙实验性根尖周病的治疗,行X线及组织学观察治疗效果,同时设有载体组(根
尖屏障材料不含rhBMP-2)和对照组(根尖屏障材料为氧化锌丁香油糊剂加牙胶尖)。结果 复合rhBMP-2治疗剂具
有X线阻射特性,实验组治疗根尖周病的有效率明显高于载体组和对照组;组织学观察显示,实验组根尖周组织新
生活跃,修复质量明显优于载体组和对照组(P
英文摘要
Objective To investigate the effect of the treatment of periapical diseaseswith recombinant human bone morphoge- netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application.Methods The endotoxin- bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical disease models were built. The rhBMP-2 composite was mixed by rhBMP-2,TCP,collagen and metronidazole and used in the treatment of periapi- cal diseases in dogmodels as root apex screen. The imageology and pathology researchwere went on.Results The effective rate of the experimental group was remarkably higherthan that of the carrier group and the control groupwith remarkable statistical dif- ference(P
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