细胞表面糖蛋白表达异常与涎腺多形性腺瘤复发的关系
The Relationship of Abnormal Expression of Cell Glucoprotein with Recurrence of Pleomorphic Adenoma in Salivary Gland
作者：高鹏,周庚寅,宋向荣,侯建新,张翠娟,马超
Author：GAO Peng, ZHOUGeng-yin, SONGXiang-rong, HOUJian-xin, ZHANG Chui-juan, MAChao
收稿日期：2005-04-25 年卷（期）页码：2005,23(02):164-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：多形性腺瘤,多形上皮粘蛋白1,E-钙粘蛋白,
Key words：plemorphic adenoma,pleomorphic epithelial mucin 1,E-cadherin,
基金项目：
国家自然科学基金资助项目(30300124);高等学校博士学科点专项科研基金资助项目(20020422042)
中文摘要
目的 研究多形上皮粘蛋白1(mucin 1)和E-钙粘蛋白(E-cd)与涎腺多形性腺瘤复发的关系,探讨可预测
涎腺多形性腺瘤复发的指标。方法 以52例涎腺多形性腺瘤石蜡标本为研究对象,其中初发33例,复发12例,恶
性7例。采用显微镜观察肿瘤周围包膜的状况,免疫组织化学检测初发、复发、恶性多形性腺瘤细胞的mucin 1和
E-cd蛋白表达情况。结果 初发和复发多形性腺瘤的包膜状况差异无显著性(P>0·05)。初发多形性腺瘤细胞的
mucin 1蛋白表达阳性率(64%)与复发者(67%)的差异无显著性(P>0·05)。两者的差别表现为mucin 1阳性表达
部位分布不同,初发者主要为细胞顶膜染色(19/21),复发者主要为整个细胞膜染色(6/8),两者差异有显著性(P0·05)。结论 多形性腺瘤的包膜状况在预测其复发潜能上实际应用性不强,多形性腺瘤细胞E-cd的表达
改变与其复发潜能无显著关系。Mucin 1在多形性腺瘤细胞膜上的异常分布,使其倾向于向周围分散生长,这种异
常分布可作为预测多形性腺瘤复发的指标之一。
英文摘要
Objective To study the relationship of expression of mucin 1 and E-cadherin with recurrence of pleomorphic ade- noma in salivary gland, and to investigate the signal to predictthe recurrence potential of the tumor.Methods The capsule of tu- mor was observed bymicroscope. The expression ofmucin 1 and E-cadherin in 33 cases of primary adenoma, 12 cases of recurrent pleomorphic adenomas and 7 cases of malignant pleomorphic adenomas were detected by immunohistochemistry.Results There was no significant difference about the status of capsule and the positive rate of mucin 1 expression between primary and recurrent pleomorphic adenoma (P>0·05). The abnormal distribution of mucin 1 expressionwas observed in recurrent pleomorphic adeno- ma (6/8), whichwas characterized by the positive staining of the whole cytomembrane. On the other hand,positive staining of the primary pleomorphic adenomawas observed on the top of the membrane (19/21). The differencewas statistically significant (P0·05). Conclusion The status of capsule didn′t have much actual usage in predicting the recurrence of pleomorphic adenoma. There was no significant relationship between the expression of E-cd and the recurrence of the tumor. The abnormal distribution of mucin 1 expression contributes to the invasiveness of the tumor and can be used as the predictive signal for recurrence of pleomorphic adenoma.
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