口腔癌术后放疗患者口腔菌群的变化
The Changes of Bacteria Group on Oral Mucosa after Radiotherapy of Postoperative Patients of Oral Carcinoma
作者：刘坤,高宁,王翼川,王昌美,王晓毅,高庆红,宣鸣,温玉明
Author：LIU Kun1, GAONing2, WANG Yi-chuan3, WANG Chang-mei1, WANGXiao-yi1, GAO Qing-hong1, XUANMing1, WENYu-ming1.
收稿日期：2005-04-25 年卷（期）页码：2005,23(02):128-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：口腔癌,放射治疗,口腔菌群,
Key words：oral carcinoma,radiotherapy,oral bacteria group,
基金项目：四川省科技攻关计划资助项目(D102SG022-021)
中文摘要
目的 了解口腔鳞癌术后放疗对患者口腔菌群的影响,为临床防治继发感染提供实验依据。方法 32例
口腔鳞癌术后患者,于放疗前后分别在照射野的中心区域与对侧黏膜采集唾液标本,进行细菌的分离培养鉴定,测
量可培养细菌的检出率、检出量和构成比。结果 与放疗前相比,放疗后照射侧和非照射侧的链球菌属、白色念珠
菌和绿脓杆菌检出增加;而照射侧的放线菌属和奈瑟菌属检出减少(P
英文摘要
Objective To investigate the microbial contents presented on the surface of mucosa in the oral cavity of patients who accepted radiotherapy, and to provide the evidences of controlling post-radiotherapeutic infections.Methods 32 patients (19 males and 13 females) aged from 37~72 received radiotherapy after oral squamous cell carcinomas operationwere selected. Sam- ples of salivawere obtained fromthe radiated center and opposite mucosa before and after radiotherapy. The detective amount, de- tective ratio and constituent ratio were analysed by cultivation and identification.Results Streptococci, Candida albicansand Pseudomonas aeruginosasignificantly increased on both sides of the oral mucosa whileNeisseriaandActinobacillusdecreased on radiated region after the radiotherapy.Conclusion Radiotherapy has great effects on oral bacteria and pathogenic organism may play a role in post-radiotherapy infections. It is necessary to do bacteria culture and choose sensitive antibiotics regularly for post- radiotherapeutic patients.
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