口腔鳞状细胞癌Fas基因表达与细胞凋亡关系的研究
Study on the Relationship between Fas Expression and Apoptosis in Oral Squamous Cell Carcinoma
作者：王建广1,黄洪章1,潘朝斌1,侯劲松2,李劲松1,程 斌3
Author：WANGJian-guang1, HUANGHong-zhang1,PANChao-bin1,HOUJin-song2,LIJin-song1,CHENG bin3
收稿日期：2004-08-25 年卷（期）页码：2004,22(04):334-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：Fas基因,鳞状细胞癌,凋亡,
Key words：Fasgene,squamouscell,carcinoma,;apoptosis,
基金项目：
中文摘要
目的 探讨Fas基因mRNA及蛋白表达水平与人口腔鳞状细胞癌细胞凋亡的关系。方法 应用Northern 杂交、双参数流式术(TUNEL法)检测人口腔鳞状细胞癌中Fas mRNA及蛋白的表达,鳞癌细胞的细胞周期与凋亡水平。结果 5例正常口腔黏膜标本中均有Fas mRNA及蛋白的表达。在口腔鳞癌组织中,Fas mRNA及蛋白的表达与口腔鳞癌组织病理学分级有关(P
英文摘要
Objective To investigate the relationship of Fas mRNA and protein expression and apoptosis in human oral squa- mous cell carcinoma.Methods Northern blot and flow cytometry (TUNELmethod) were used to detectthe expression of FasmR- NA and Fas protein, cell cycle and apoptotic level in oral squamous cell carcinoma. The relationship between Fas gene expression and OSCC apoptosis was analyzed statistically.Results Fas mRNA and protein could be detected in all five normal oral mucosa specimens. There was positive correlation between expression of Fas mRNA/protein and cell differentiation as well as apoptosis in OSCC(P
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