派丽奥与牙康治疗牙周炎的疗效比较
A Comparison between the Effects of Periocline and Yakang on the Treatment of Periodontitis
作者：孙颖,吴亚菲,肖晓蓉,丁一,朱硃
Author：SUNYing1,WUYa-fei1, XIAOXiao-rong2,DING Yi1,ZHUZhu2
收稿日期：2004-08-25 年卷（期）页码：2004,22(04):290-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：盐酸米诺环素,甲硝唑,牙周炎,龈下微生物,
Key words：minocycline hydrochoride,metronidazole,periodontitis,subgingival microbe,
基金项目：
中文摘要
目的 比较派丽奥(2%盐酸米诺环素软膏)与牙康(甲硝唑棒)治疗牙周炎的临床疗效及对牙周可疑致病菌的清除作用。方法 选取11例慢性牙周炎患者的26颗牙周炎患牙为研究对象。患牙要求:①牙周袋探诊深度≥4 mm,且探诊后出血;②左右对称。26颗患牙随机分成实验组(派丽奥治疗组)13颗,对照组(牙康治疗组)13 颗。观察用药前及用药后7 d和14 d,患牙的牙周临床指标菌斑指数(PLI)、牙龈指数(GI)、探诊深度(PD)、探诊出血(BOP)的变化和龈下附着菌斑中螺旋体、球菌、杆菌的百分比,以及非附着菌斑中牙龈卟啉单胞菌、中间普氏菌、二氧化碳噬纤维菌等牙周可疑致病菌百分比的变化。结果 实验组和对照组患牙在用药前各项牙周临床指标和微生物学指标均无显著性差异(P>0.05)。用药后,两组患牙绝大部分牙周临床指标和微生物学指标均较用药前明显改善(P0.05)。结论 派丽奥与牙康均是治疗牙周炎有效、安全的局部治疗药物,两者的疗效无显著性差异。
英文摘要
Objective To compare the efficacy of 2 available periodontal systems for local delivery of antibiotics.Methods 26 teeth with moderate to severe periodontitis (PD≥4 mm) from 11 patientswere selected. The teethwere randomly divided into test group and control group. Periocline (2% minocycline hydrochoride ointment) was applied tothe teeth in the test group, while Ya- kang (local metronidazole) was applied in the control group. The data including clinical indices and microbiological parameters was collected before and on the 7th, 14thday after the therapy.Results Before treatment, the mean of each clinical indices and microbiological parameters between the two groups was not different (P>0.05). But both groups demonstrated significant differ- ences with control after treatment (P0. 05).Conclusion Both Periocline and Yakang were effective and secure local delivery drug for treating periodontitis.
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