淋巴靶向平阳霉素—活性炭纳米微粒的研制
Preparation of Lymphatic Targeting Dosage Form: Pingyangmycin Absorbed on Activated Carbon Nanoparticles
作者：孙明磊1,温玉明2,王昌美2,李龙江2,王晓毅2
Author：Ming-lei1,WEN Yu-ming2, WANG Chang-mei2, LILong-jiang2, WANGXiao-yi2
收稿日期：2004-06-25 年卷（期）页码：2004,22(03):183-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：平阳霉素,活性炭,纳米微粒,口腔癌,淋巴转移,
Key words：pingyangmycin,activated carbon,nanoparticle,oral cancer,lymph metastasis,
基金项目：卫生部科学基金资助项目(98-1-221)
中文摘要
目的 制备淋巴结靶向性抗癌纳米微粒———平阳霉素—活性炭纳米微粒,用于治疗口腔癌颈淋巴结转移灶。方法 制备活性炭纳米微粒(CH-NP),选择对口腔癌高度敏感的平阳霉素(PYM)为模型药物,考察活性炭纳米微粒对平阳霉素吸附效率。结果 活性炭纳米微粒的粒径分布为136~540 nm,平均粒径为178 nm,活性炭纳米微粒投入比例的增高,对平阳霉素的吸附率相应增高,10∶1质量比下可达到99·38%的吸附。结论 活性炭纳米微粒对平阳霉素的吸附率高,制备PYM-CH-NP行口腔癌周局部注射可使靶向淋巴结转移灶获得有效治疗效果。
英文摘要
Objective To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.Meth- ods The activated carbon nanoparticles(CH-NP) were prepared for drug carrier. Pingyangmycin(PYM), a high sensitive anti- cancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYMwas absorbed on activated carbon enough, resulting in a newformulation of PYM (PYM-CH-NP). The absorbency of PYMon activated carbon nanoparticles was evaluated.Results The diameter distribu- tion for CH-NP ranged form 136 nmto 540 nm, the average diameterwas 176 nm.The proportion of CH-NPto PYMwas increased and more absorbency of PYMon activated carbon nanoparticleswas achieved.Conclusion The activated carbon nanoparticles has high absorbency of PYM. The newformulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.
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