nm23-H1基因在口腔鳞癌颈淋巴结转移不同阶段的调控作用
The Regulation of nm23-H1/NDPK-A in Different Processes of Regional Lymph Node Metastases of Oral Squamous Cell Carcinomas
作者：杨湛,温玉明,普苹,付红梅,汤炀,李继梅
Author：YANG Zhan*,WENYuming,PUPing,et al.
收稿日期：2003-08-25 年卷（期）页码：2003,21(04):263-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：nm23-H1基因,口腔鳞癌,淋巴结转移,
Key words：nm23-H1/NDPK-A,lymph node,metastases,oral squamous cell carcinomas,
基金项目：
本课题为云南省自然科学基金资助项目(编号96C137Q, 2000C0012R)
中文摘要
目的 探讨nm23-H1基因在口腔鳞癌区域淋巴结转移不同阶段的调控作用及影响。方法 利用免疫组化和Western Blot技术,结合淋巴结转移和原发灶浸润分型的资料,分组对照研究nm23-H1基因在200例口腔鳞癌颈淋巴结转移不同阶段的表达情况。结果 淋巴结转移组nm23-H1基因阴性表达率明显高于无淋巴结转移组(P
英文摘要
Objective To study the regulation and effect of the expression of nm23-H1 gene in different processes of re- gional lymph node metastases of oral squamous cell carcinomas(OSCC).Methods By immunohistochemical analysis in 200 paraf- fin-embedded tissues of OSCC and Western Blot in 9 fresh tissues of OSCC using a monoclonal antibody, the expression of nm23-H1/NDPK-Awere detected in dividing groups accompanied with the clinical and pathological data of cervical lymph node metastases and modes of invasion.Results The rates of negative expression of nm23-H1/NDPK-A had significant differences be- tween metastatic cases(34/81) and non-metastatic cases(15/119). The nm23-H1/NDPK-A negative group showed higher frequen- cy of lymph node metasteses (P
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