口腔黏膜组织结构及DNA损伤修复功能的增龄性变化
A Study on Age-related Changes of Histological Structure and DNA Repair Capacity in Oral Mucosa
作者：周红梅,杨娅,周敏,郑晓晖,王智,何志秀,李秉琦
Author：ZHOU Hongmei*, YANG Ya, ZHOU Min, et al.
收稿日期：2003-06-25 年卷（期）页码：2003,21(03):177-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：增龄性变化,组织结构,P53蛋白表达,DNA损伤修复功能,口腔黏膜,
Key words：age-related changes,histological structure,P53 protein expression,DNA repair capacity,oral mucosa,
基金项目：国家自然科学基金资助项目 (编号 30070815)
中文摘要
目的 研究口腔黏膜组织结构及DNA损伤修复功能 (以P5 3蛋白表达为指标 )的增龄性变化 ,探讨老年人好发口腔鳞状细胞癌的可能机制。方法 以不同年龄健康人 的正常口腔黏膜组织作为实验对象 ,分别采用常规HE染色法和免疫组织化学技术 (SP法 ) ,研究各组口腔黏膜组织结构特征及P5 3蛋白表达情况 ,并用半定量法对SP染色结果进行判定。结果 ①随年龄的增长 ,口腔黏膜组织结构发生系列变化 ;②随年龄增长 ,口腔黏膜组织中P5 3阳性表达率增高 ,染色分值也呈上升趋势 (P
英文摘要
Objective To investigate the age-related changes of histological structure and DNA repair capacity (P53 protein expression) in oral mucous membrane and try to explain why the elders are prone to oral squamous cell carcinoma.Methods\ The routine HE staining and an immunohistochemical technical (SP method) were used respectively to study the changes of histological structure and P53 expression in normal oral mucosa of different age groups. The SP staining results were evaluated by semi-quantity method.Results ①With aging, a series of histological changes were observed in the oral mucosa; ② With aging, an elevating tendency of P53 protein level emerged in the oral mucosa (P
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