尿激酶型纤溶酶原激活物在口腔鳞癌中的表达及意义
The Expression of Urokinase-type Plasminogen Activator in Oral Squamous Cell Carcinoma
作者：梁新华,毛祖彝,何永文,肖贵州,吴军楼
Author：LIANGXinhua*,MAO Zuyi,HE Yongwen,et al.
收稿日期：2003-04-25 年卷（期）页码：2003,21(02):147-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：口腔鳞状细胞癌,尿激酶型纤溶酶原激活物,浸润,转移,预后,
Key words：oral squamous cell carcinoma,urokinase-type plasminogen activator,invasion,metastasis,prognosis,
基金项目：
中文摘要
目的 探讨尿激酶型纤溶酶原激活物(UPA)在口腔鳞癌中的表达及与侵袭、转移、预后的关系。方法 采用免疫组织化学LsAB法检测80例口腔鳞癌、10例口腔正常粘膜、10例口腔粘膜白斑中UPA的表达。结果 口腔鳞癌中UPA表达明显高于口腔正常粘膜和口腔白斑。口腔鳞癌中UPA的表达与淋巴结转移、预后、生长方式存在相关关系;有转移者表达明显高于无转移者,预后差者表达明显高于预后好者,浸润型生长方式者表达高于外生型和溃疡型生长方式者。结论 UPA表达与口腔鳞癌的侵袭、转移关系密切,有望在临床上成为判断侵袭、转移和预后指标之一。
英文摘要
Objective The aim of this studywas to reveal the relations between expression and tumor behavior such as in- vasion, metastasis and prognosis in oral squamous cell carcinoma (SCC) through analyzing the expression of urokinase-type plas- minogen activator (UPA).Methods With Labelled streptavidin biotin method (LsAB), the expression of UPAwas analyzed in 80 cases of oral squamous cell carcinoma, 10 cases of oral normal mucosa and 10 cases of oral leukoplakia.Results Compared to oral normal mucosa and oral leukoplakia, the expression ofUPAwas significantly higher in SCC. The expression ofUPA in SCC cases with lymph node metastasiswas significantly higherthan in caseswithoutmetastasis. The expression in caseswith good prog- nosiswas significantly higher than in those with poor prognosis and the expression was significantly higher in cases with invasive growth than in those with ulcerative and papillary growth.Conclusion The results obtained indicated that high expression ofUPA in SCC might be closely related to lymph node metastasis, invasive growth and poor prognosis.
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