Objective To investigate the life quality and their influence factors in cleft lip and palate parents and to provide evidences for improving the life quality of the parents.Methods One hundred and forty-three parents whose children accepted the primary surgery of cleft lip and palate were selected as the case group, and 109 normal adults as the control group. Both groups were investigated by 3 questionnaires that included questionnaire of general status, generic quality of life inventory-74(GQOLI-74), social support rating scale(SSRS). The results of two groups were analyzed and the influence factors on life quality were studied by stepwise multiple regression analysis.Results 1)The scores of the life quality, mental function, social function, material life in the case group were significantly low com-pared with the control group(P<0.05). 2)The social support total scores, subjective support and utilization of social sup-port were lower than the control group(PConclusion The life quality and social support of cleft lip and palate patients is poor, we should give more support and help to improve their life quality.