We reported one case of a patient with Sjögren’s syndrome and dental implant. This patient was followed up for more than one year. The patient was diagnosed with Sjögren’s syndrome for 5 years and treated with long-term corticosteroid. Four implant-tissue interface hydrophilic implants were placed on 15, 16, 44, and 46 of the mandibular and maxillary areas. After the surgery was completed, the patient was treated with oral antibiotic and “shenggu pills” to prevent infection and glucocorticoid to manage Sjögren’s syndrome. Consequently, six implants were placed in other parts of the mandibular and maxillary areas. After more than one year of follow-up, the implants and prosthesis remained stable and had no complications. Cone beam CT reconstruction showed good implant-bone combination.
