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论文摘要

宁夏地区非综合征型唇腭裂环境因素的研究

Association between non-syndromic cleft lip with or without cleft palate and environmental factors in Ningxia

作者:于丽丽, 马坚, 高俊鹏, 翟堃, 朱晋芳, 黄永清

Author:Lili Yu, Jian Ma, Junpeng Gao, Kun Zhai, Jinfang Zhu, Yongqing Huang

收稿日期:2016-06-17          年卷(期)页码:2017,35(3):291-291-295

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:非综合征型唇腭裂,环境因素,Logistic回归分析,

Key words:non-syndromic cleft lip with or without cleft palate,environmental factor,Logistic regression analysis,

基金项目:国家自然科学基金(81560181);宁夏医科大学特殊人才启动项目(XT2015018);宁夏自然科学基金(NZ14116)

中文摘要

目的 探讨宁夏地区非综合征型唇腭裂(NSCL/P)发病相关环境因素。方法 采用病例对照研究方法纳入NSCL/P患者453例,正常新生儿452例。对研究对象进行问卷调查,利用SPSS 16.0统计软件对数据进行卡方检验和Logistic回归分析。结果 NSCL/P患病类型构成比为唇裂︰唇裂合并腭裂︰腭裂=1︰2.02︰1.51。Logistic回归分析显示妊娠期发生异常、妊娠期感染、流产史、孕前孕中服用药物、饮茶、吸烟、饮酒、居住地附近工厂为危险因素(P<0.05)。单胎、早孕反应、食用豆制品食物、水果为保护因素(P<0.05)。结论 加强母亲孕期饮食均衡,避免感染、流产、服用药物以及不良生活习惯对降低NSCL/P的发生具有重要意义。

英文摘要

ObjectiveTo investigate the association between non-syndromic cleft lip with or without cleft palate (NSCL/P) and environmental factors in Ningxia population.MethodsThis case-control study involved 453 NSCL/P patients and 452 normal newborns from Ningxia. A questionnaire focusing on various factors, including family history, pregnancy reaction, drug use during pregnancy, and infections, was used and responses were analyzed through Chi-square test and Logistic regres-sion analysis with SPSS 16.0.ResultsThe constituent ratio of different types of NSCL/P was cleft lip∶cleft lip and palate∶cleft palate equal to 1︰2.02︰1.51. Logistic regression analysis revealed that abnormal pregnancy, infection, abortion, drugs, drinking, smoking, and living near factories likely increased the risk of NSCL/P (P<0 .05). single fetus, pregnancy-related nausea, vomiting, parents’ moderate tastes, and eating soy foods and fruits decreased the risk of nscl/p (P<0 .05).ConclusionThe incidence of NSCL/P should be reduced to enhance the conditions of women during pregnancy by maintaining a balanced diet and avoiding infections, abortion, drugs, and negative habits.

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