髓样细胞触发受体1和2与恶性肿瘤关系的研究进展
Research progress on the relationship between triggering receptor expressed on myeloid cells 1 and 2 and malignant tumors
作者：杨芸, 吴武超, 吴亚菲, 赵蕾
Author：Yun Yang, Wuchao Wu, Yafei Wu, Lei. Zhao
收稿日期：2016-08-11 年卷（期）页码：2017,35(6):648-648-653
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：髓样细胞触发受体-1,髓样细胞触发受体-2,慢性炎症,恶性肿瘤,
Key words：triggering receptor expressed on myeloid cells 1,triggering receptor expressed on myeloid cells 2,chronic inflammation,malignant tumour,
基金项目：国家自然科学基金（81371150）;留学回国人员科研启动基金（2013-693-11-11）
中文摘要
越来越多的证据支持炎症与肿瘤形成的相关性,其中模式识别受体启动的免疫应答对于肿瘤相关炎症的触发至关重要。髓样细胞触发受体（TREM）是一种新近发现的免疫球蛋白跨膜受体超家族,主要表达于髓样细胞,其最主要家族成员为TREM-1和TREM-2。它们通过与配体结合被激活后发生交联反应,从而调节炎症反应。近年来,TREM与恶性肿瘤之间的关系得到广泛关注与研究。本文就TREM-1和TREM-2与恶性肿瘤关系在医学领域的研究进展作一综述,以期为牙周炎与口腔肿瘤的相关关联研究提供思路。
英文摘要
Increasing scientific evidence supports the positive relationship between inflammation and cancer development. The immune response initiated by pattern recognition receptors is critical to triggering of tumor-associated inflammation. Triggering receptor expressed on myeloid cells (TREM) is an immunoglobulin of the super transmembrane glycoprotein family, which is mainly expressed on select groups of myeloid cells. The most important members of TREM comprise TREM-1 and TREM-2. Activation of TREM-1 and TREM-2 signaling is initiated upon binding of their ligands. Subsequently, cross-linking reactions of downstream effectors occur, resulting in inflammation regulation. Recently, the connection between TREM and malignant tumors has been widely noticed and studied. This review summarizes studies of association between TREM-1, TREM-2, and malignant tumors in the medical field to provide new ideas for study on the correlation between periodontitis and oral cavity cancer.
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