Objective To observe and evaluate the clinical performance of zirconia crowns made by CEREC inLab com-puter aided design/computer aided manufacturing(CAD/CAM) for posterior teeth.Methods A total of 242 patients were implanted with zirconia crowns fabricated by CEREC inLab CAD/CAM. The crowns were evaluated by Modified US Public Health Service criteria at baseline, 6, 12, 24, and 36 months. The chi-square test was used to analyze the survival rate.Results All but five crowns were evaluated by an independent evaluator at baseline, 6, 12, 24, and 36 months. The survival rate de-clined with time. The A score percentage was above 85% at 36 months.ConclusionThe single zirconia crowns fabricated by CEREC inLab CAD/CAM demonstrate satisfactory clinical performance during a short period.