釉质早期龋的光学相干断层成像与定量研究
Imaging and quantitative analysis of early caries using optical coherence tomography
作者：李燕妮 姚晖 连小丽 王冠华 代晓华 张林朴
Author：Li Yanni, Yao Hui, Lian Xiaoli, Wang Guanhua, Dai Xiaohua, Zhang Linpu.
收稿日期：2014-05-21 年卷（期）页码：2015,33(2):121-121-124
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：光学相干断层成像技术,早期龋,矿质改变,光学成像,量化评估,
Key words：optical coherence tomography,early caries,mineral change,optical imaging,quantitative evaluation,
基金项目：
国家自然科学基金面上基金资助项目（30770597）
中文摘要
目的 探讨光学相干断层成像技术（OCT）对釉质早期龋的成像和量化评估效能，为其在早期龋临床诊断中的应用提供实验依据。方法 采用OCT扫描牛牙光滑面早期人工龋模型和脱矿模型，获取釉质图像和光学信息，并与偏振光显微镜图像和原子吸收光谱测得的矿质损失量进行对比，采用SPSS软件包配对t检验和Pearson相关性分析进行数据分析。结果 早期龋及脱矿釉质OCT图像与偏光显微镜图像基本相符；OCT测得的早期龋组釉质的总反射率改变量低于脱矿组（P0.05）。釉质总反射率改变量与矿质损失量呈正相关（P结论 OCT能够无创地、较准确地显示釉质早期龋的矿质改变，量化其病变范围和程度，在早期龋的临床诊断方面具有广阔的应用前景。
英文摘要
ObjectiveTo explore the efficacy of optical coherence tomography (OCT) in imaging and quantitatively evaluating early enamel caries and provide experimental evidence for the clinical diagnosis of early caries.MethodsThe smooth surface of bovine teeth showing early artificial caries and demineralization changes was scanned by an all fiber-based OCT for images and optical profiles, which were compared with images from a polarized light microscope (PLM) and mineral loss from an atomic absorption spectrometer. Data were analyzed by paired-sample t-test and Pearson correlation analysis using SPSS software.ResultsThe images of enamel with early caries and demineralization from OCT coincided with those from PLM. The integrated reflectivity loss in the early caries group was significantly lower than that in the demineralized group (P0.05). A linear correlation was observed between integrated reflectivity loss and mineral loss (PConclusionOCT can be used to nondestructively and accurately image early caries and quantify lesion extent and degree, suggesting the extensive use of this approach in the clinical diagnosis of early caries.
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