凝血酶敏感蛋白-1与口腔颌面部恶性肿瘤发生发展的关系
Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy
作者：周雪琴,任俊,杨森
Author：Xueqin Zhou,Jun Ren,Sen Yang
收稿日期：2018-01-11 年卷（期）页码：2018,36(6):686-686-690
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：口腔颌面部恶性肿瘤,凝血酶敏感蛋白-1,实体肿瘤,血管抑制,
Key words：oral and maxillofacial malignancy,thrombospondin-1,solid tumor,vascular suppression,
基金项目：中华口腔医学会西部行口腔医学临床科研基金(CSA-W2016-01);四川省科技支撑计划项目(2014SZ0038);四川省医学科研青年创新课题(Q14054);四川省科技计划重点研发项目(20-18FZ0113)
中文摘要
凝血酶敏感蛋白- 1（TSP-1）作为一种重要的抑制血管生成物质,在人体组织中广泛分布,并且在不同组织部位肿瘤的形成、生长、分化、转移中占据不可代替的地位。TSP-1在各类肿瘤（如膀胱癌、乳腺癌、前列腺癌、非小细胞肺癌、胰腺癌等）的发生、发展中起着重要的作用,近年研究证实凝血酶敏感蛋白-1对口腔颌面部恶性肿瘤血管生成及肿瘤发生、发展的抑制作用也尤为明显。本文对TSP-1在全身肿瘤及口腔颌面部恶性肿瘤中的研究进展进行综述。
英文摘要
Thrombospondin-1 (TSP-1) is widely distributed in human tissues and is important in inhibiting angiogenesis.It also occupies an indispensable position in the formation, growth, differentiation, and metastasis of tumors in different tissues.TSP-1 plays an important role in the occurrence and development of various types of tumors. The inhibitory effect of TSP-1 on the angiogenesis and tumor development of oral and maxillofacial malignant tumors has been demonstrated in recent years. This paper reviews the findings and progress of TSP-1 research involving all kinds of tumors as well as oral and maxillofacial malignancies.
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