血小板衍生生长因子对大鼠种植体周围神经再生影响的研究
Effects of platelet-derived growth factor on nerve regeneration around implant in rats
作者：王艳颖,宫苹,张健
Author：Yanying Wang,Ping Gong,Jian Zhang
收稿日期：2018-08-20 年卷（期）页码：2019,37(4):350-350-354
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：血小板衍生生长因子,种植体,神经纤维,神经再生,骨感知,
Key words：platelet-derived growth factor,implant,nerve fiber,nerve regeneration,osseoperception,
基金项目：国家自然科学基金面上项目(81571008);天津市口腔医院博硕士重点课题项目(2015BSZD08);生物活性材料教育部重点实验室（南开大学）开放基金(2018003)
中文摘要
目的 探讨血小板衍生生长因子（PDGF）对大鼠种植体周围神经再生的影响。方法 建立大鼠股骨植入种植体模型,愈合早期连续注射PDGF,采用免疫组化染色的方法分析PDGF对种植体周围神经再生的影响。结果 PDGF增加大鼠股骨种植体周围早期神经纤维数量,对种植体周围后期神经纤维数量无显著影响。同时,这些神经具有周围神经纤维的典型结构。结论 PDGF可以促进种植体周围早期神经再生。本研究为实现PDGF促进种植体周围神经再生,进而改善种植体感觉功能的临床应用,提供一定的实验依据。
英文摘要
ObjectiveTo investigate the effect of platelet-derived growth factor (PDGF) on nerve regeneration in peri-implant tissues.MethodsSD rats with implants in their femurs were injected with PDGF solution. The effects of PDGF on nerve regeneration in peri-implant tissues were analyzed by immunohistochemical staining.ResultsPDGF increased the number of nerve fibers in peri-implant tissues at early stage. PDGF had no significant effect on the number of nerve fibers in peri-implant tissues at late stage. Moreover, these nerves had a typical structure of peripheral nerve fibers.ConclusionPDGF can promote nerve regeneration in peri-implant tissues at early stage. This study provided a certain experimental basis for the clinical application of PDGF to promote nerve regeneration and further improve the sensory function of the implant.
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