吸烟对慢性牙周炎牙龈微循环影响的初步研究
Preliminary study on the effects of smoking on gingival microcirculation in chronic periodontitis
作者：王旭,石磊,应绚,童钰鑫,张佳喻,石旭妍,陈悦
Author：Wang Xu,Shi Lei,Ying Xuan,Tong Yuxin,Zhang Jiayu,Shi Xuyan,Chen Yue
收稿日期：2019-03-31 年卷（期）页码：2019,37(5):485-485-489
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：牙龈血流量,微血管密度,慢性牙周炎,
Key words：gingival blood flow,microvessels density,chronic periodontitis,
基金项目：陕西省自然科学基金基础研究计划(2018JM7116)
中文摘要
目的 从牙龈微循环方面探讨吸烟促进慢性牙周炎的机制。方法 试验一选取慢性牙周炎吸烟患者（A组）、慢性牙周炎不吸烟患者（B组）、牙周健康不吸烟志愿者（C组）上前牙各102颗,应用激光多普勒血流仪进行上前牙区牙龈血流量（GBF）检测。试验二根据是否吸烟将牙周翻瓣术中取材牙龈分为吸烟组（A’组）和不吸烟组（B’组）,并将牙周健康不吸烟者行牙冠延长术或埋伏阻生智齿拔除术中取材牙龈作为对照组（C’组）,通过组织切片进行3组牙龈组织微血管密度（MVD）计数。采用SPSS 22.0软件包进行数据统计分析。结果 B组与C组相比,各牙位GBF均有增加,其中12牙、21牙、23牙差异有统计学意义（PPP>0.05）。结论 牙周炎症会引起GBF、牙龈MVD的增高,但吸烟并不会引起牙龈微循环（GBF、MVD）的显著变化,尚不支持吸烟通过影响牙龈微循环促进慢性牙周炎发生发展这一机制。
英文摘要
ObjectiveTo explore the mechanism of smoking that promotes chronic periodontitis from the perspective of gingival microcirculation.MethodsIn experiment one, upper anterior teeth (n=102) from smokers with chronic periodontitis (Group A), nonsmokers with chronic periodontitis (Group B), and nonsmokers with healthy periodontal conditions (Group C) were selected to undergo gingival blood flow (GBF) through laser doppler flowmetry. In experiment two, the tissues obtained from gums during periodontal flap surgery were divided into smoking (Group A’) and nonsmoking (Group B’) groups, and the gingival tissue obtained from periodontal healthy nonsmokers treated with crown lengthening surgery or impacted wisdom tooth extraction served as the control group (Group C’). The microvessels density (MVD) of the gingival tissue from the three groups was determined in the tissue sections. SPSS 22.0 was used for statistical analysis.ResultsCompared with group C, GBF of all teeth increased in group B, and there were significant differences among 12, 21 and 23 teeth. MVD significantly differed between Group B’ and C’ (PConclusionPeriodontitis can increase GBF and MVD, but smoking does not cause significant changes. However, the mechanism by which smoking promotes the occurrence and development of chronic periodontitis by influencing gingival microcirculation has not been discussed in this research.
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