Objective To observe the effect of OHOLV on the remineralization of early enamel caries.Methods Fifty bovine teeth with artificial early caries were divided into five groups randomly and treated with OHOLV, casein phosphopeptide amorphous calcium phosphate (CPP-ACP), NaF, OHOLV+NaF and distilled and deionized water (DDW) respectively. Then the teeth were subjected to the pH -cycling. The surface microhardness (SMH) of enamel before demineralization and after remineralization were measured by microhardness detector and the histomorphologic changes of the enamel surface were compared by scanning election microscope (SEM) .Results The SMH of all the experi - mental groups increased significantly after remineralization (P0.05) . After remineralization, a large amount of comparatively large mineral particles deposited on the surface of the enamel treated with OHOLV.Conclusion OHOLV can promote the remineralization of the early enamel caries.