口腔肿瘤患者精神心理因素评估及相关物质基础的初步研究
Preliminary study of assessment of mental health level among oral tumor patients and difference of relevant material basis
作者：李博 李黎 段泽西 黄一冰 潘唯一 郭黛墨 邹晓莉 朱彩蓉 谢蟪旭
Author：Li Bo, Li Li, Duan Zexi, Huang Yibing, Pan Weiyi, Guo Daimo, Zou Xiaoli, Zhu Cairong, Xie Huixu
收稿日期： 年卷（期）页码：2014,32(1):45-45-50
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：症状自评量表, 口腔肿瘤, 高效液相色谱-质谱,
Key words：symptomchecklist-90, oral tumor, highper formance liquid chromatography-tandem masss pectrometry,
基金项目：
中文摘要
目的 认识口腔肿瘤患者及配偶的精神心理因素变化规律，探索其相关物质基础。方法 选取 2011年12月—2012年8月间四川大学华西口腔医院确诊的口腔恶性肿瘤患者 40例、良性肿瘤患者 35例、恶性肿瘤配偶 18例，应用症状自评量表（ SCL90）按照 5级评分标准，测评每位受试者精神心理状况。于入院次日上午 9点抽取受试者的全血，分离提取血清，采用高效液相色谱 -质谱分析血清中儿茶酚胺以及糖皮质激素含量。结果 恶性肿瘤组强迫症状、抑郁与其他因子分均高于良性肿瘤组，差异有统计学意义（P结论 口腔肿瘤患者存在明显的精神心理因素变化，同时伴有机体内相关物质变化，影响着恶性肿瘤的发生发展，对进一步研究恶性肿瘤疾病进程的相关机制及探索干预方法有重要价值。
英文摘要
Objective To investigate the difference in mental health status of oral tumor patients and their spouses, and explore the differences on the basis of relevant materials.Methods Forty patients with oral cancer, eighteen spouses, and thirty-five patients with oral benign tumor were diagnosed in the West China Hospital of Stomatology between December 2011 and August 2012 and assessed with symptom checklist-90(SCL90) (the 5-grade scoring). Participants were assessed independently according to their conditions. Blood samples were obtained from the participants by syringe on the second admission day. A method was developed to determine the concentrations of catecholamine and glucocorticoid in the serum using high performance liquid chromatography-tandemmassspectrometry(HPLC-MS/MS).Results The scores for compel,depression and rests in the cancer group and benign tumor group were statistically significant (PConclusion Psychiatric factors do not show a simple factor effect on patients. Symptoms of patients may be based on tumorigenesis and developed in small molecules.Further research is required.
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