Objective To evaluate the efficacy of periodontal treatment for the management of cardiovascular risk fac-tors.Methods Eligible studies in Cochrane Controlled Trials Register/CENTRAL, PubMed, EMBASE, and China Biology Medicine disc (CBMdisc) were searched until October 13, 2011. References of the included studies were hand searched. Two reviewers assessed the risk of bias and extracted the data of the included studies in duplicate. Meta-analysis was con-ducted with Revman 5.1.Results Six randomized controlled trials involving 682 participants were included. One case had low risk of bias, another one had moderate risk of bias, and the remaining four had high risk of bias. Meta-analysis showed that periodontal treatment has no significant effect on C-reactive protein, total cholesterol, low-density lipoprotein cholesterol, and triglycerides (P>0.05). However, the treatment had a significant effect on high-density lipoprotein cholesterol [MD=0.05, 95% CI (0.00, 0.09), P=0.04].Conclusion Periodontal treatment has good effects on controlling high-density lipo-protein cholesterol although more randomized controlled trials must be conducted to verify its effectiveness.
