饮酒和细胞外超氧化物岐化酶、乙醛脱氢酶2基因多态性与口腔鳞状细胞癌的相关性研究
Correlation between drinking behavior and polymorphisms of extracellular superoxide dismutase, aldehyde dehy-drogenase 2 genes, and oral squamous cell carcinoma
作者：张超贤 郭李柯 史淑敏
Author：Zhang Chaoxian, Guo Like, Shi Shumin
收稿日期：2013-08-15 年卷（期）页码：2014,32(2):119-119-124
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：口腔鳞状细胞癌,细胞外超氧化物岐化酶,乙醛脱氢酶2,多态现象,饮酒行为,
Key words：oral squamous cell carcinoma,extracellu-lar superoxide dismutase, aldehyde dehydrogenase 2,polymorphism,drinking,
基金项目：
中文摘要
目的 探讨饮酒和细胞外超氧化物岐化酶（EC-SOD）、乙醛脱氢酶2（ALDH2）基因多态性与口腔鳞状细胞癌患病之间的关系。方法 采用病例对照研究的方法，以750例口腔鳞状细胞癌患者（病例组）及750例非癌对照者（对照组）的外周血白细胞为样本，采用聚合酶链反应（PCR）技术分析EC-SOD和ALDH2基因的多态性，并分析该基因多态性与口腔鳞状细胞癌患病的关系。结果 病例组EC-SOD（C/G）和ALDH2变异基因型频率分别为38.27%、69.47%，对照组则为21.07%、44.40%，二者差异有统计学意义（P结论 EC-SOD及ALDH2变异基因型和饮酒是口腔鳞状细胞癌的易患因素，三者联合在口腔鳞状细胞癌的发生中有协同作用。
英文摘要
Objective To investigate the correlation between drinking behavior and polymorphism combination of extracel-lular superoxide dismutase (EC-SOD) and aldehyde dehydrogenase 2 (ALDH2) genes and oral squamous cell carcinoma.Methods The genetic polymorphisms of EC-SOD and ALDH2 were analyzed by polymorphism-polymerase chain reaction technique in peripheral blood leukocytes of 750 oral squamous cell carcinoma cases and 750 non-cancer controls.Results The frequencies of EC-SOD (C/G) and ALDH2 variant genotypes were 38.27% and 69.47% in oral squamous cell carcinoma cases and 21.07% and 44.40% in healthy controls, respectively. Statistical tests showed significant difference in the frequencies between the two groups (PConclusion EC-SOD (C/G) and ALDH2 variant genotypes and drinking are the risk factors in oral squamous cell carcinoma, which could carry out a coordinated attack of oral squamous cell carcinoma.
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