Objective To study the expression of vascular endothelial growth factor-C（VEGF-C） in oral squamous cell carcinoma（OSCC） and its relation to angiogenesis, lymphangiogenesis, as well as lymph node metastasis. Methods Sixty-seven archival specimens from patients with oral squamous cell carcinoma were investigated, whose clinicopathologic data were completely conserved. Immunohistochemical staining was performed to detect the expression of VEGF-C, microvessel density（MVD）, lymphatic vessel density（LVD）. The correlations between VEGF-C expression and MVD, LVD, as well as other clinicopathological features were measured. Results Although no correlation between VEGF-C expression and tumor location, histological grade, or gender of the patients was observed（P>0.05）, OSCC patients with more advanced clinical stages and lymph node metastasis were prone to have high expression of VEGF-C（P=0.015 and P
