A family with Angle′s Class Ⅱ malocclusion was identified in West China Stomatological Hospital of Sichuan University. The proband was a 22 -year -old woman with Angle′ s Class Ⅱ Division 2 malocclusion with congenitally missing teeth. A total of 15 members of the 3 generations in the family were investigated. There were 7 members（3 males, 4 females） with Angle′s Class Ⅱ malocclusion in the family. The results provide the primary basis for further study to localize the virulence gene.
