Objective To investigate the expression and correlation of mast cell, Clusterin/apoJ and transforming growth factor-β(TGF-β) in the different stages of human dermal hemangioma. Methods Immunohistochemical stain technique(SABC) and toluidine blue(TB) stain technique were respectively used to detect the expression level of Clusterin/apoJ and TGF-β and the number of mast cells in the different stages of human dermal hemangioma. Results There was remarkable statistical difference between the advanced stage of proliferative hemangioma and the other stages of proliferative hemangioma in the number of mast cell(P