Objective To research the expression of CD31, CD34 and CD105 in squamous cell carcinoma of tongue（TSCC） and discuss their relationships with lymph node metastasis. Methods All the specimens′segments were stained by immunohistochemical method SP, and then the tumor′s microvessel density（MVD）marked by CD31, CD34 and CD105 were counted by the Weidner′s method. Results The expression of CD31, CD34 and CD105 in the tumor′s tissue was much higher than that in the normal tissue（P0.05）, but they were obviously different from which marked by CD105（P0.05）. The MVD values marked by CD31 and CD34 had no statistical difference in different pathological grades and clinical stages（P>0.05）, but there was statistical difference in different pathological grades and clinical stages marked by CD105（P
