缓释骨形态发生蛋白-2的壳聚糖温敏凝胶促进牙周组织再生的实验研究

Objective To observe the effect of the chitosan thermosensitive hydrogel loading recombinant human bone morphogenetic protein- 2（rhBMP- 2） on repairing periodontal defects. Methods To prepare artificial furcation defects model in the posterior area in 3 healthy male dogs, and then to inject chitosan thermosensitive hydrogel loading of rhBMP- 2 after fast suturing tissue flap. The groups filled with nothing or filled only with chitosan thermosensitive hydrogel were the controls. The dogs were sacrificed after 8 weeks and the periodontal regeneration was observed histologically. Results The histological observation showed that the chitosan thermosensitive hydrogel loading rhBMP- 2 group achieved apparent periodontal tissue regeneration occupying the majority of the defects and the control groups got only a small amount of periodontal tissue regeneration. Conclusion The chitosan thermosensitive hydrogel loading rhBMP- 2 can effectively promote the periodontal tissue regeneration, while simplifying the surgical operation. It might be a potential means for periodontal regeneration.