Objective To investigate the treatment of perioperative period on maxillofacial patients with diabetes. Methods The retrospective analysis was taken on clinical data of 24 cases of maxillofacial patients with diabetes. Results All patients recovered without severe complications by controlling blood sugar during whole stage and preventing infection with antibiotics after surgery. The wounds in 21 cases healed in 10- 14 days after the operations and that didn′t in 3 cases. With the treatment on local wounds, the wounds in 3 cases healed in 14- 28 days after the operations. Conclusion It′s the treatment principle of maxillofacial surgical patients with diabetes to monitor the levels of blood glucose on time, to control the levels of blood glucose rigorously at the whole stage and to prevent complication.