Objective To study the characteristics of thyroglossal tract cyst epidemiology and summarize how to improve the operation therapeutic effect. Methods The clinic appearance, the pathological characteristics and the therapeutic effect of the 60 thyroglossal tract cyst cases were analyzed. Results Thyroglossal tract cyst mostly occurred in children and teenagers. The incidence of female patients was more than that of male patients. Most of thyroglossal tract cyst located in the middle line of the neck and were explored tubular - objects and fibroropes. The histopathological feature was variform. Conclusion The clinical appearance and pathology charaeristic of thyroglossal tract cyst are variform. Thyroglossal tract cyst may be recurred easily if it is not operated well.