Objective Summarizing the value and key point of combined use of local block anesthesia and general anesthesia in cleft lip repairing for infants.Methods Local block anesthesia and general anesthesiawere combined to use in 120 cleft lip re- pairing operation of infants usingMidazolam, Fentangl, Ketamine, Scoline (orVecuronium) in intubation, and injecting 0.5%~ 1% lidocaine of which contained 1/250 000 adrenalinum. While intubation and operation, BP, P, R, SpO2, T and ECG were observed clearly. After operation, extubation was delayed and breathing oxygen was used for infants with breathing airway infec- tion.Results While operation, anesthesia of 120 infants was smooth. After operation, the infants regain conscious quickly and no accident occurred.Conclusion For the cleft lip repairing operation to infants, as combined use of local block anesthesia and general anesthesia, anesthesia is smooth, internal environment of body is steady, bleeding is little, regaining consciousness is quick and the infants are safe.