p16和nm23基因在唾液腺肿瘤中表达的研究
Expression of p16 and nm23 Genes in Salivary Gland Tumors
作者：龚莉,陈照立,胡佳,贺红焰
Author：GONG Li,CHEN Zhao-li,HU Jia,HUO Hong-yan.
收稿日期：2004-04-25 年卷（期）页码：2004,22(02):155-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：p16基因,nm23基因,唾液腺肿瘤,免疫组织化学,
Key words：p16 gene,nm23 gene,salivary gland tumors,immunohistochemistry,
基金项目：
四川省教委青年基金资助项目(川教计〔1999〕164号)
中文摘要
目的 探讨p16和nm23基因在唾液腺良、恶性肿瘤中的表达情况及与唾液腺肿瘤发生之间的关系。方法 用免疫组织化学SABC法检测39例正常唾液腺和唾液腺肿瘤存档石蜡标本中P16蛋白和nm23蛋白的表达。结果 P16和nm23蛋白阳性表达主要见于细胞浆及细胞核,呈棕黄色。在正常唾液腺中,二者阳性表达率均为100% (4/4)。在良性和恶性唾液腺肿瘤中,P16蛋白阳性表达率分别为76·9%(10/13)和40·9%(9/22),良恶性之间P16蛋白表达差异有统计学意义(P
英文摘要
Objective To study the expression of p16 and nm23 genes in salivary gland tumors and the relation of P16 and nm23 proteins with tumorigenesis of salivary gland tumors.Methods Expression of P16 and nm23 proteins was examined by SABC immunohistochemical method in 39 cases of paraffin blocks of normal salivary gland tissues and salivary gland tumors.Re- sults P16 and nm23 protein positive stainingwere mainly found in the cytoplasm and cytoblast of all salivary gland tissues. Posi- tive rate of P16 protein expressionwas 76·9%(10/13) and 40·9%(9/22) in benign and malignant salivary gland tumors, respec- tively. There was signioficant difference between P16 protein expression of benign and malignant tumors byχ2test (P0·05).Conclusion p16 and nm23 genes may play an im- portant role in different sides in salivary gland tumorigenesis and the reduce of the expression of p16 and nm23 genes may contrib- ute to the generation of malignant salivary gland tumors.
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