Objective The purpose of this article was to observe the effect of by microwave thermocoagulation on oral benign tumor and to provide theoretical basis for clinic treatment of oral benign tumor.Methods 165 patients with oral benign tumor were included. There were 83 patientswith oral bursa cyst, 42 patientswith hemangioma, 19 patientswith papilloma, 14 patients with fibrous hyperplasia and 7 patientswith epulis. All the patientswere treated by WB-100 microwave thermocoagulation.Results 144 patientswere effective afterthe first treatment and 21 patientswere effective afterthe second treatments. No side effect and reoccurrence were found after 3 years.Conclusion Microwave thermocoagulation is an effective and safe method in clinic treat- ment of oral benign tumor.