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论文摘要

功能矫形前伸下颌后大鼠髁突软骨细胞睾酮的分布变化规律

Expression of Testosterone in the Rapid Growing Rat Condylar Cartilage and the Expression Changes after the Function Mandibular Advacement

作者:李小兵,陈开云,周征,罗颂椒

Author:LIXiao-bin,CHENKai-yun,ZHOU Zheng,LUO Song-jiao

收稿日期:2004-02-25          年卷(期)页码:2004,22(01):29-

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:睾酮,功能矫形,髁突软骨,

Key words:testosterone,functional orthopedics,condylar cartilage,

基金项目:国家自然科学基金资助项目(39470760)

中文摘要

目的 研究快速生长期大鼠髁突软骨细胞睾酮的表达,并探讨功能矫形对髁突软骨细胞睾酮表达的影响。方法 实验组戴自制模拟的功能矫治器引导大鼠下颌前伸,在实验第3天、1、2、3及4周处死大鼠,应用免疫组织化学SP法检测睾酮在髁突软骨细胞上的表达特点。结果 ①实验组、对照组大鼠髁突软骨细胞各层都有睾酮的阳性免疫染色,大鼠各层细胞中以成熟层及移行层阳性强度较高,明显高于生发层及过渡层,其中成熟层染色强度最高;②随着大鼠的青春期生长发育,髁突软骨细胞各层睾酮染色强度出现不同的变化特点;③实验第2及第 3周组大鼠髁突成熟层软骨细胞睾酮染色强度明显高于对照各组,差异具有统计学意义(P

英文摘要

Objective To investigate the expressions ofTestosterone in the condylar cartilage of rapid growing rats.Methods The mimic functional appliances were used in experiment groups and rats were killed after 3 days , 1week, 2weeks, 3weeks and 4weeks. Immunohistochemical technique was used to detect the expression ofT.Results Twas expressed throughout the condy- lar cartilage. TheHighest expressionswere in mature layers of both experiment and control groups. Alongwith the maturation, the expressions of T in the condylar cartilage were changed respectively, and the immunostain levels in the mature layer of experiment groups 2 and 3 weekswere higherthan those of control groups (P

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