脱矿牙本质基质用于根尖诱导成形术的临床研究
Clinical Studies on Apexification with Demineralized Dentin Matrix
作者：蒋月桂,孙沫逸,吴鸫,孙剑
Author：JIANG Yuegui*,SUNMoyi,WUDong,et al.
收稿日期：2003-12-25 年卷（期）页码：2003,21(06):460-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：脱矿牙本质基质,骨形成蛋白,氢氧化钙,根尖诱导成形术,
Key words：demineralized dentin matrix (DDM),bone morphogenetic proteins (BMP),calcium hydroxide,apexification,
基金项目：
中文摘要
目的 观察同种脱矿牙本质基质(DDM)用于根尖诱导成形术的临床效果。方法 将人牙本质去脂、脱矿粉碎、冻干等处理制备成DDM,作为根尖诱导剂应用于临床,并以氢氧化钙糊剂作为对照,共治疗患牙57颗。分别于术后1年、2年拍X线片及临床检查。结果 根尖诱导成形术后1年,患牙X线片有不同程度的根尖屏障形成,或虽无明显的X线改变但根管内探测有明显阻力,此时更换永久性根管充填材料。术后2年的临床观察发现, DDM组的治愈率为92·86%,略高于氢氧化钙组的91·30%,但无显著性差异。结论 脱矿牙本质基质可作为一种新的根尖诱导剂应用于临床。
英文摘要
Objective To studythe clinical effects of demineralized dentinmatrix (DDM) as a apexificating agent.Meth- ods Human teeth were crushed into fragments and were defated, demineralized, lyophilized to produce DDM. The DDM was used as an apexificating agent to treat 57 teeth compared with calcium hydroxide. X-ray film and clinical observation were under- taken after half a year, one year and two years.Results One year later, a barrier in the tooth apexwas found in the X-rays film. Then permanent filling material was used. After two years, DDM group had a healing rate of 92·86%, was higher than that of 91·30% in calcium hydroxide group, but there were no statistical significance.Conclusion The findings suggest that DDM can be used as a new apexificating agent. One year after the apexification is the best opportunity to change the apexificating agent to a permanent root canal filling material.
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