成釉细胞瘤中Ki-67的表达及其临床意义
Expression of Ki-67 Antigen in Ameloblastoma and its Clinical Significance
作者：韩波,李龙江,王虎,郑广宁
Author：HANBo*,LILongjiang,WANGHu,et al.
收稿日期：2003-04-25 年卷（期）页码：2003,21(02):153-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：成釉细胞瘤,Ki-67抗原,免疫组织化学,
Key words：ameloblastoma,Ki-67 antigen,immunohistochemistry,
基金项目：本课题为四川省杰出青年基金资助项目(编号G9949)
中文摘要
目的 检测Ki-67抗原在不同组织类型成釉细胞瘤中的表达情况,以探讨不同组织类型成釉细胞瘤的细胞增殖能力差异及其相应的临床意义。方法 采用LsAB免疫组织化学方法,对70例成釉细胞瘤进行染色, 并采用Sopt及IPP图像分析系统半定量分析Ki-67阳性染色指数。结果 恶性成釉细胞瘤的阳性染色指数最高 14·72%±2·87%,其次为实性成釉细胞瘤,其中以滤泡型4·42%±1·05%高于丛状型3·64%±1·23%,单囊型最低 2·21%±1·09%。结论 Ki-67所反映的不同组织类型成釉细胞瘤的细胞增殖能力的差异,可能与其术后复发率的高低有关。
英文摘要
Objective The expression ofKi-67 antigen of ameloblastomawas exmanied in orderto investigate the different proliferation activity of histological variants of ameloblastoma and its clinical significance.Methods 70 cases of different histolog- ical specimen of ameloblastoma were analyzed by immunohistochemical method using Ki-67 antibody. The Label Indexwas calcu- lated in percentage of Ki-67 positive cells after examinedwith an image analysis system.Results The results showed that the La- beled Index in malignant ameloblastoma was the highest 14·72%±2·87%. The Labeled Index in solid ameloblastoma was in the middle, among which the follicular 4·42%±1·05% was higher than the plexiform 3·64%±1·23%. The Labeled Index in mono-cystic ameloblastoma was the lowest 2·21%±1·09%.Conclusion The results demonstrated that the proliferation activity varied according to the histological pattern of ameloblastoma. The prognosis with different proliferation activitywas also varied ac- cordingly.
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