加热对人舌癌Tca8113细胞尿激酶型纤溶酶原激活物表达的影响
The Effect of Heat Shock on the Expression of Urokinase-type Plasminogen Activator in Human Tongue Squamous Cell Carcinoma Cell Line (Tca8113)
作者：梁新华,肖贵州,毛祖彝,吴军楼,何永文
Author：LIANGXinhua*,XIAO Guizhou,MAO Zuyi,et al.
收稿日期：2003-04-25 年卷（期）页码：2003,21(02):150-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：尿激酶型纤溶酶原激活物,热疗,舌鳞状细胞癌,侵袭,转移,
Key words：urokinase-type plasminogen activator,hyperthermia,tongue squamous cell carcinoma,invasion, metastasis,
基金项目：
中文摘要
目的 研究加热对人舌癌Tca8113细胞尿激酶型纤溶酶原激活物(UPA)表达的影响。方法 采用免疫组织化学染色和流式细胞术检测Tca8113细胞在不同加热温度下(37℃、40℃、43℃、45℃)UPA表达情况。结果 与37℃组相比,40℃、43℃组加热后Tca8113细胞UPA表达明显下降(P0·05)。结论 口腔鳞癌局部热疗不会促进侵袭、转移,还会对肿瘤的侵袭、转移有抑制作用。
英文摘要
Objective The aim of this studywas to observe the expression of urokinase-type plasminogen activator (UPA) in human tongue squamous cell carcinoma cell line (Tca8113) after heat shockwith different dosage.Methods The expression of UPA protein ofTca8113 after different heating temperatures(37℃、40℃、43℃and 45℃) treatmentwas examined by immuno- histochemical technique (IH) and flow cytometry (FCM).Results Compared with 37℃group, the UPA protein expression in 40℃and 43℃groups decreased significantly (P
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