Objective:The purpose of this study was to investigate effects of chemotherapy on tongue squamous cell carcinoma by detecting the apoptosis, proliferation and expression of Bcl-2.Methods: A total of 60 samples were studied, including tongue squamous cell carcinomas with chemotherapy (10 cases), tongue squamous cell carcinomas (30 cases), tongue squamous cell papillomas (20 cases) . The samples were investigated using immunohistochemical stain and in situ detection technique. Results: The apoptosis index (AI) was significantly lower in the group of squamous cell carcinomas compared with the squamous cell papillomas, but the proliferation index (PI) in the former group was significantly higher than the latter( P
