成釉细胞纤维瘤与成釉细胞纤维肉瘤
Ameloblastic Fibroma and Ameloblastic Fibrosarcoma
作者：钟鸣,王洁,王兆元,韩有平
Author：ZhongMing, Wang Jie, Wang Zhaoyuan, et al
收稿日期：2002-04-25 年卷（期）页码：2002,20(02):134-
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：成釉细胞纤维瘤,成釉细胞纤维肉瘤,牙源性肿瘤,
Key words：ameloblastic fibroma,ameloblastic fibrosarcoma,odontogenic tumor,
基金项目：
中文摘要
目的:观察成釉细胞纤维瘤(ameloblastic fibroma, AF)及成釉细胞纤维肉瘤(ameloblastic fibrosarcoma, AFS)的间质成份,探讨其与临床生物学行为的关系。方法:14例肿物(AF 11例,AFS 3例)切片经HE染色,光镜下观察,5例新鲜标本(AF 3例,AFS 2例)取材后电镜观察。结果:11例AF中有3例复发,复发率为2713%,复发时间分别是术后半年、1年、10年。3例AFS中1例为原发,2例为AF恶变而来。组织病理学显示AF中成釉细胞上皮成分散布于富含纤维粘液样结缔组织中,间质成分主要为成纤维细胞,此外,可见组织样细胞和纤维组织样细胞及少量未分化间叶细胞。AFS中间质成纤维细胞密集增生,胞核浓染,核浆比例失调有明显异型性,其中2例成釉细胞上皮成份明显减少或缺如。结论:AF间质细胞具有一定的增殖活性,经各种刺激可恶变为AFS。AFS中的上皮减少和缺如可与间质细胞的过度增生恶变有关。AFS间质的细胞具有明显的恶性特征。
英文摘要
Objective: The objective of this studywas to observe the interstitial cell of ameloblastic fibroma (AF) and ameloblastic fibro- sarcoma (AFS) and elucidate their biological characters.Methods: 11 cases of AF (in these 3 cases recurred) and 3 cases of AFS (in these 3 cases recurred and changed malignantly) were stained by HE, scanned by lightmicroscope, in which 5 cases of fresh tumor tissue, including 3 cases of AF and 2 cases of AFS, were scanned by the electric microscope.Results: Comparing with AF, interstitial cells of AFS increased, and atypical cells were usually present. Fibroblasts, fibrohistocytes, histocytes, un- differentiated mesenchymal cells and myofibroblasts were also found in the tumor tissue. The ameloblastic epitheliums was lack in 2P3 AFS.Conclusion: Decreased or lack epithelia may be associated with excessive hyperplasia in AFS. Interstitial cells of AFS may transform malignantly due to various stimulation.
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