Objective This study aims to compare and determine a kind of nano-hydroxyapatite composite material with good antibacterial efficacy onEnterococcus faecalis(E. faecalis)in vitro.Methods We investigated the antimicrobial activity of four kinds of nano-hydroxyapatite composites, namely, silver/hydroxyapatite composite nanoparticles (Ag/nHA), yttrium/hydroxyapatite composite nanoparticles (Yi/nHA), cerium/hydroxyapatite composite nanoparticles (Ce/nHA), and hydroxyapatite nanoparticles (nHA), againstE. faecalis in vitrousing the agar diffusion and broth dilution method by measuring the growth inhibition zone and the minimum inhibitory concentration (MIC), respectively.Results The agar diffusion test results showed that Ag/nHA displayed an obvious growth inhibition zone, whereas Yi/nHA, Ce/nHA, and nHA showed no influence onE. faecalis. The MIC value of Ag/nHA was 1.0 g·L-1, and the three other materials had no effect onE. faecaliseven at the high concentration of 32.0 g·L-1.Conclusion Ag/nHA display a potential antimicrobial efficacy to planktonicE. faecalis. Whereas, the three other kinds of nano-hydroxyapatite composites (Yi/nHA, Ce/nHA, nHA) show no influence.
