马尾松松针提取物对根面牙本质脱矿影响的体外研究
Effect of Pinus massoniana needle extract on root dentin demineralization in vitro
作者：唐成芳 阮建平 朱勇 李子夏 左艳萍 徐红艳
Author：Tang Chengfang, Ruan Jianping, Zhu Yong, Li Zixia, Zuo Yanping, Xu Hongyan.
收稿日期：2016-03-15 年卷（期）页码：2016,34(5):521-521-525
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：马尾松松针提取物,根面龋,牙本质,脱矿,矿物密度,
Key words：Pinus massoniana needle extract,root caries,dentin,demineralization,mineral density,
基金项目：
陕西省科技厅社会发展项目（2015SF242）；陕西省教育厅科研课题（15JK1625）；西安医学院博士启动基金（2015DOC20）；西安医学院重点学科资助
中文摘要
目的 评价马尾松松针提取物（PMNE）抑制根面牙本质脱矿的效果。方法 将根面牙本质块根据pH循环中所用实验溶液随机分为去离子蒸馏水（DDW）组，氟化钠（NaF）组，4%、8%和12%PMNE组，试件进行为期8 d的pH循环。显微CT选区测定各组未脱矿牙本质和脱矿牙本质的牙本质矿物密度（DMD）及两者DMD差值（ΔDMD），扫描电镜下观察pH循环后牙本质表面形貌。结果 PMNE各组和NaF组ΔDMD均显著低于DDW组（P0.05），均显著低于4%PMNE组，高于NaF组（P结论 PMNE可抑制根面牙本质脱矿，减缓酸对DMD的降低，具有一定的抗龋活性。8%PMNE即可达到较好抑制脱矿的效果。
英文摘要
Objective This study aims to evaluate the effects of Pinus massoniana needle extract (PMNE) on inhibiting demineralization of root dentin.Methods Root dentin blocks were randomly divided into distilled deionized water (DDW) group, fluoride sodium (NaF) group, and 4%, 8% and 12% PMNE groups according to the experimental solution used in the process of pH cycling in each group. All specimens in each group experienced pH cycling for 8 d. The dentin mineral density (DMD) of the normal dentin and demineralized dentin and their D-value (ΔDMD) were determined using micro computed tomography. The morphology of dentin surface after pH cycling was also observed using a scanning electron microscope.Results The ΔDMD values in all PMNE groups and the NaF group were considerably lower than the ΔDMD in the DDW group (P0.05), both of which were lower than the ΔDMD in the 4% PMNE group and higher than that in the NaF group (PConclusion PMNE can inhibit the demineralization of root dentin and can slow down the reduction in DMD. PMNE has the potential to prevent caries, and 8% PMNE can effectively inhibit dentin demineralization.
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