Some transcriptional regulators contribute to the expression ofStreptococcus mutans(S. mutans) cariogenicvirulence factors. Although the target sequence transcriptional regulators anchored on the cell wall and the molecular mechanismof the regulation ofS. mutansare yet to be clarified, certain global regulators potentially associated with the cariogenicityofS. mutanshave been identified. This review is about these related transcriptional regulators, their function, and possiblemechanisms.